Bin Wang, Fei Luo, Wei-Ting Zhang and Ji-Sheng HanCA
Neuroscience Research Institute,Beijing Medical University, 38 Xueyuan Road, Beijing 100083, P. R. China
CACorresponding Author
Received 23 May 2000; accepted 14 June 2000
To construct a model for the relapse of drug use, we investigated the reinstatement of morphine-induced conditioned place preference (CPP) in rats. After the morphine CPP paradigm was established, rats were left extinguishing for 9 days, then exposed to 15 min of random foot shock or s.c. drug priming with different doses of morphine or amphetamine, respectively. Foot shock or a higher dose (0.25 mg/kg) of both drugs could reinstate the CPP induced by 4 mg/kg of morphine after a 9-day extinction, while a lower dose (0.125 mg/kg) of both drugs had no effect. It is concluded that the CPP extinction±reinstatement paradigm might be used as a model to investigate the mechanism of relapse in addicts.
NeuroReport 11:2781±2784 & 2000 Lippincott Williams & Wilkins.
Key words: Amphetamine; Conditioned place preference; Extinction; Morphine; Opioid addiction; Psychological dependence; Reinstatement; Relapse; Stress
