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张松莲 ，一， 曾富华 ， ，喻宁华 ，一，饶力群2
(1．湛江师范学院应用生命科学研究所，广东湛汀524048；2．湖南农业大学生物科学与技术学院，长沙410128)
摘要：miRNAs是真核生物中的一类5’端带磷酸基团、3’端带羟基、长度在22 nt左右的内源性非编码调控RNAs。miRNAs在控制植物的发育、开花时序、新陈代谢、应激反应等方面起着重要的作用。已知植物miRNAs在转录后水平上抑制基因表达，主要是通过导致mRNA的裂解，对抑制目标转录物的翻译起作用。另外其也能在转录水平上通过决定目标染色体位点的甲基化而起作用。对植物miRNAs的功能及作用机制的研究现状做一综述。
关键词：综述；miRNA；siRNA；RISC；Dicer；目标mRNA裂解；翻译抑制
中图分类号：Q946．222 文献标识码：A 文章编号：1005—3395(2006)05—0444—07
Advances in Studies on the Function
and M echanism ecIianism OoIf Plant M icroRNA
ZHANG Song一1 ian '2， ZENG Fu—hua '2 ， YU Ning—hua '2， RA0 Li—qun
(1．Applied Institute ofrife Science，Zhanjiang Normal College，Zhanjiang 524048，China；
2．rife Science& Technology College，Hunan Agriculturol University，Changsha 410128，China)
Abstact： miRNAs are approximately 22一nucleotide endogenesis noncoding regulated RNAs in eukaryotes that have phosphate group at 5’end and hydroxy group at 3’end，which attract extensive attention in recent years．Scientists are now on the threshold of a beter understanding how miRNAs works． miRNAs plays an important role in controlling plant development，florescence time，metabolism，response to stress，etc．Plant miRNAs are known to repress gene expression post—transcriptiOnally， mainly by gu iding mRNA cleavage but also by atenuating the translation oftarget transcripts．In addition，it has been shown that plant miRNAs can also act at the transcriptional level by directing the methylation of target chromosomal loci．This paper reviews recent researches
on the function and mechaism ofplant microRNA．
Key words：Review；miRNA：siRNA：RISC；Dicer：Targeting mRNAs for cleavage；Translational repression

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